Question: What is the essential role of AGO2 within the RNA-induced silencing complex (RISC)? Answer: AGO2 is the catalytic engine of the RISC, possessing specialized endonuclease activity often referred to as "Slicer" function. It directly binds to small interfering RNAs (siRNAs) or microRNAs (miRNAs) to guide the sequence-specific cleavage of complementary target mRNA transcripts. Utilizing...
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