TGF-β signaling blockade has proven to be efficient in preventing the development of a variety of tumor types and has led to the development of vaccines targeting the production of TGF-β. Supported by advanced technology and dedicated research teams, Creative Biolabs provides services to generate TGF-β gene-modified cancer cell lines based on our client requirements and project specifications.

TGFβ Functions in T cell Activation

Transforming growth factor beta (TGF-β) is a multipotent immunosuppressive cytokine and plays an integral role in regulating immune responses. In cancer, TGF-β has been shown to support the evasion of cancer cells from immune surveillance and to contribute to the subversion of the immune system from being an extrinsic tumor suppressor to a promoter of malignant growth and spread.

TGF-β has sweeping inhibitory effects on the immune system, negatively affecting many immune cell types and functions, including:

• Inhibition of CD8+T cells functions like target recognition, cytotoxicity, and proliferation
• Inhibition of the proliferation of T cells
• Inhibition o the differentiation of both CD4+ and CD8+ naive T cells into effectors
• Suppression of effector Th cell differentiation
• Conversion of naïve T cells into regulatory T cells
• Inhibition of the proliferation of B cells
• Inhibition of the production of proinflammatory cytokines from macrophages, B cells, and T cells
• Suppression of macrophages, dendritic cells (DCs) and natural killer (NK) cells